Vetoryl 30 mg

INDICATIONS:

Treatment of hyperadrenocorticism (Cushing's disease and syndrome) pituitary or adrenal origin in dogs.

TARGET SPECIES:

Dogs.

CONTRAINDICATIONS:

Do not use in animals with primary liver disease and / or kidney failure. Do not use in animals with weight

kg.No divide less than 3 capsules.

ADVERSE REACTIONS:

In dogs treated with trilostane, there has been lethargy, vomiting, diarrhea and anorexia in the absence of evidence

hypoadrenocorticism. In dogs treated with Vetoryl have referred isolated cases of adrenal necrosis, which can

hypoadrenocorticism cause. May be unmasked subclinical renal dysfunction after treatment with the

product.The may unmask arthritis treatment due to a reduction in the levels of endogenous corticosteroids.

Have referenced a small number of cases of sudden death during adverse effects tratamiento.Otros

mild and infrequent presentation include ataxia, hypersalivation, bloating, muscle tremors and

skin disorders.

DOSAGE AND DOSAGE:

It is administered orally, once daily, with food. In clinical studies, the initial dose was effective half

6 mg / kg once daily. The dose should be adjusted according to individual response as determined by the

monitoring the patient. The following are recommended starting doses:

Body weight starting dose Dosage

<3 kg and <10 mg 3.10 Kg 30 mg / Kg

<10 kg and <20 kg 60 mg 3-6 mg / Kg

<20 kg and <40 mg 3-6 Kg 120 mg / Kg

<40 kg 120-240 mg 3-6 mg / Kg

ADVICE ON CORRECT ADMINISTRATION:

A small number of animals may require substantially higher doses than 10 mg / kg / day. In these situations,

made appropriate additional monitoring. Specimens for biochemical analysis (including

electrolytes) and performed ACTH stimulation tests (at 4-6 hours after administration) before starting the

treatment, after 10 days, 4 weeks and 12 weeks of this and later, every three months, both after

initial diagnosis and following dose adjustments.

SPECIAL STORAGE:

Do not store above 25 ° C.

Keep out of the reach and sight of children. Do not use after the expiration date shown on

the container.

SPECIAL PRECAUTIONS FOR USE:

Since most cases of hyperadrenocorticism are diagnosed in dogs aged between 10 and 15 years,

concomitant presence of other disease processes is often. In particular, it is important to rule initially

existence of primary liver disease and renal failure, as the product is contraindicated in these cases.

During treatment should be closely monitored. Special attention should be paid to the enzymes

liver, electrolytes, urea and creatinine. The concomitant presence of diabetes mellitus and hyperadrenocorticism

requires specific monitoring. If a dog has been previously treated with mitotane, adrenal function is

reduced.

The practical experience suggests that it should be a gap of one month between the end of the administration of

mitotane and trilostane treatment initiation. We recommend close monitoring of adrenal function, and

these dogs may be more sensitive to the effects of trilostane.

Use during pregnancy and lactation:

Do not use in dogs during pregnancy or lactation or in animals intended for breeding.

DRUG INTERACTIONS AND OTHER FORMS OF INTERACTION:

Should be considered the risk of hyperkalemia when used with trilostane sparing diuretics

potassium or inhibitory drugs angiotensin converting enzyme.

Veterinary prescription.

PRESENTATIONS:

30 capsules.