MODULIS is a cyclosporin oral solution that allows the dog to treat the atopic dermatitis with greater flexibility, not only treating itching but also inflammation through its immunomodulatory effect. As it is formulated in oral solution, it is possible to adjust the dose in a more precise and individualized way allowing to optimize the costs of the treatment.
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Cyclosporine is the reference treatment
MODULIS has a concentration of 100 mg / ml so the amount to be given in each intake is very small, only 1 ml per 20 kg. To make it easier for the owner to calculate and adjust the dose, each bottle comes with a graduated syringe in both ml and kg. Modulis also allows to choose the size of the package according to the duration of the treatment, with vials of 5, 15, 30 and 50 ml.
Special precautions for use
The clinical symptoms of atopic dermatitis such as pruritus and inflammation of the skin are not specific to this disease, so before starting treatment it is necessary to rule out other causes of dermatitis such as ectoparasitic infestations, other allergies that cause dermatological signs. eg flea allergy or food allergy) or bacterial and fungal infections. It is good practice to treat flea infestations before and during the treatment of atopic dermatitis.
It is recommended to eliminate bacterial and fungal infections before administering the veterinary drug. However, the occurrence of infections during treatment is not necessarily a reason to discontinue it, unless the infection is severe.
A full clinical examination should be performed prior to treatment. Since cyclosporin inhibits T lymphocytes, and although it does not induce tumors, it can lead to an increase in the incidence of clinically manifest malignant tumors.
Lymphadenopathy observed during cyclosporine treatment should be monitored regularly.
The use of cyclosporin in diabetic dogs is not recommended.
Monitor closely the creatinine levels in dogs with severe renal impairment.
Special attention should be paid to vaccinations. Treatment with the veterinary medicinal product may interfere with the effectiveness of vaccination. In the case of inactivated vaccines, vaccination is not recommended during treatment or within two weeks before or after administration of the veterinary medicinal product.
It is not recommended to use other immunosuppressive drugs simultaneously.
Specific precautions to be taken by the person administering the veterinary medicinal product to animals Persons with known hypersensitivity to cyclosporin should avoid any contact with the veterinary medicinal product.
Wash your hands after administration.
In case of accidental contact of the veterinary medicinal product with the skin or eyes, rinse the affected area thoroughly with clean water.
In case of accidental ingestion, consult a physician immediately and show the package insert or label.
Posology and method of administration
The recommended mean dose of cyclosporin is 5 mg / kg body weight, equivalent to 0.5 ml solution per 10 kg body weight.
The veterinary medicinal product should initially be administered daily until satisfactory clinical improvement is observed. This usually happens within 4 weeks. If no response is obtained within the first 8 weeks, treatment should be discontinued.
Once the clinical symptoms of atopic dermatitis have been satisfactorily controlled, the veterinary medicinal product can be administered every two days as a maintenance dose.
The veterinarian should perform a clinical evaluation at regular intervals and adjust the frequency of administration to the clinical response obtained.
In some cases where clinical symptoms are controlled with a dosage every two days, the veterinarian may decide to give the veterinary drug every 3 to 4 days.
Before reducing the interval between dosages it may be considered to give an additional treatment (eg medicated shampoos, essential fatty acids).
Treatment may be discontinued when clinical symptoms are controlled. If clinical symptoms recur, treatment should be resumed with a daily dose and, in some cases, repeated treatment schedules may be necessary.
The veterinary medicinal product should be administered at least 2 hours before or after meals.
The veterinary medicinal product should be administered directly into the mouth.
Instructions for use
For 5 and 15 ml bottles
Volume to be administered using the 1 ml syringe: 0.05 ml / kg, ie 1 graduation / kg.
For 30 and 50 ml bottles
Volume to be administered using the 2 ml syringe: 0,1 ml / 2 kg, ie 1 graduation / 2 kg.
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