• Liver diseases.
Food supplement based on SAM (S-Adenosylmethionine), Silybin, Vitamin E, Zinc and Selenium for liver diseases.
HEPATOSIL PLUS is a food supplement based on SAM (S-Adenosylmethionine), Silybin, Vitamin E, Zinc and Selenium indicated for liver disease. SAM is an enzyme that activates transmethylation, transsulfuration and aminopropylation reactions, which are crucial for detoxicating the liver. It increases glutathione levels; the greatest physiological defence against oxidative stress involved in the pathogenesis of liver conditions. It also preserves cell membrane integrity and reduces hepatic fibrosis. Silybin is the most active flavonolignan of Silymarin; a mixture of different flavonolignans found in the integument of the fruit of the milk thistle (Silybum marianum). It stimulates the liver’s regeneration capacity and new hepatocyte production. As an antihepatotoxic agent, it prevents hepatotoxic agents from reaching the cells. Besides reducing hepatic fibrosis, it inhibits leukotriene synthesis, reducing inflammatory processes, and also has an immunemodulating effect. Selenium forms part of glutathione peroxidase, an essential enzyme in reducing the oxidative damage caused by free oxygen radicals. It enhances antioxidant defences by increasing SOD (superoxide dismutase) levels, and it has an antiinflammatory effect by reducing interleukin IL-6 transcription. Vitamin E (a-tocopherol) protects hepatocytes against oxidative damage, enabling the liver to function normally. Zinc acts as an hepatoprotector by inhibiting lipid peroxidation and stabilising the membranes; it also has an antifibrotic effect as, by chelating copper, it inhibits lysyl oxidase, and acts as a cytoprotector by inhibiting the production of oxygen-reactive species and protecting sulphidril groups from oxidation.
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