Tablets for treating congestive heart failure in dogs.
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|Hidrocloruro de benazepril||Espironolactona|
|Cardalis 2,5 mg/20 mg||2,5 mg||20 mg|
|Cardalis 5 mg/40 mg||5 mg||40 mg|
|Cardalis 10 mg/80 mg||10 mg||80 mg|
Interactions and incompatibilities
• No adverse interactions have been observed with furosemide .
• With other antihypertensive agents ( eg calcium channel blockers , β -blockers or diuretics ) , anesthetics or sedatives may be adding hypotensive effects .
• With potassium sparing other treatments (such as β -blockers , calcium channel blockers , blockers of angiotensin receptors , etc.). Hyperkalemia may occur .
• With NSAIDs can reduce the antihypertensive effect , the natriuretic effect and increase blood potassium level . Therefore, dogs treated together with an NSAID should be monitored closely and be properly hydrated.
• With desoxicorticoesterona can be observed a modest reduction in the natriuretic effects ( reduction of urinary sodium excretion ) of spironolactone .
• Spironolactone decreases clearance of digoxin. Since the therapeutic index for digoxin is very narrow , it is recommended to carefully monitor dogs receiving a combination of digoxin and spironolactone and benazepril (HCl ) .
• Spironolactone may cause both induction and inhibition of cytochrome P450 enzymes may affect the metabolism of other substances using these metabolic pathways .
Indications and species of destination
Dogs : Treatment of congestive heart failure caused by chronic degenerative valvular disease canine ( with the complementary use of a diuretic , when necessary ) .
• Do not use during pregnancy or lactation or in animals or who intends to allocate to reproduction.
• Do not use in dogs suffering from hypoadrenocorticism , hyperkalaemia or hyponatraemia .
• Do not use NSAIDs in dogs with renal failure .
• Do not use in case of hypersensitivity to inhibitors of angiotensin converting enzyme ( ACE ) or any of the excipients .
• Do not use in cases of failure in cardiac output due to aortic or pulmonary stenosis .
In male dogs treated with spironolactone is frequently observed reversible prostatic atrophy .
Route of administration
Dogs: 2 mg of spironolactone / kg and 0.25 mg of benazepril hydrochloride / kg, once a day .
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