Broad spectrum internal antiparasitic for large breed dogs that eliminates both roundworms and flatworms.
Composition equivalent to Drontal Plus XL
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Indications for use , specifying the target species them
In dogs: treatment of mixed infestations by roundworms and tapeworms of the following species
Ascaris: Toxocara canis, Toxascaris leonina (adults and immature forms advanced).
Hookworms: stenocephala hookworm, Ancylostoma caninum (adults).
Tricuros: Trichuris vulpis (adults).
Tapeworms: Echinococcus spp., (E. granulosus, E. multilocularis), Taenia spp., (T.hydatigena, pisiformis T., T. taeniformis), Dipylidium caninum (adults and immature forms).
Do not use simultaneously with piperazine compounds.
Do not use in animals with known hypersensitivity to the active substances or to any of the excipients.
Special warnings for each target species
Fleas serve as intermediate hosts for one common type of tapeworm: Dipylidiu caninum. Tapeworm infestation surely be repeated unless control is effected intermediate hosts (fleas, mice, etc.).
Tapeworm Infestation is unlikely in pups less than 6 weeks of age.
Parasite resistance to any particular class of anthelmintic may develop using an anthelmintic of that class frequently and repeatedly.
Special precautions for use
Special precautions for use in animals
Partially used tablets should be discarded.
To ensure a correct dosage, the weight should be determined as accurately as possible.
Precautions to be taken by the person administering the medicinal product to animals
In case of accidental ingestion, seek medical advice and show the package leaflet.
In order to maintain good hygiene, persons administering the tablets directly or adding them to the dog's food should wash their hands after administration.
Adverse reactions (frequency and seriousness)
Use during pregnancy and lactation
Teratogenic effects attributed to high doses of febantel have been observed in rats and sheep. No studies in dogs during the early stage of gestation. The use of the drug during pregnancy should be performed according to a risk-benefit assessment by the responsible veterinarian. You should not use the medication in dogs during the first 4 weeks of gestation. Do not exceed the recommended dose for the treatment of pregnant bitches.
Interaction with other medicinal products and other forms of interaction
Do not use simultaneously with piperazine compounds, as anthelmintic effects pyrantel, and piperazine can be antagonistic.
Concomitant use with other cholinergic compounds can cause toxicity.
Dosage and Administration
Only for oral administration.
Recommended doses are 15 mg febantel / kg body weight, pyrantel 5 mg / kg (equivalent to 14.4 mg and praziquantel, pyrantel embonate 5 mg / kg.
Equal 1 tablet per 10 kg Prazitel body weight.
The tablets can be given directly to the dog or hidden in food. It is not necessary to fast before or after treatment.
If risk of reinfestation, you should consult a veterinarian about the need and frequency of repeat administration.
Overdose (symptoms, emergency procedures, antidotes), if necessary
The combination of praziquantel, pyrantel embonate and febantel is well tolerated in dogs. In safety studies, doses 5 times the recommended or higher caused occasional vomiting.
Pharmacotherapeutic group: anthelmintic, praziquantel combinations.
This product contains anthelmintics active against gastrointestinal nematodes and tapeworms. The medicine contains three active ingredients:
1. Febantel, a probenzimidazol.
2. Pyrantel embonate (pamoate), a tetrahydropyrimidine derivative.
3. Praziquantel, a partially hydrogenated derivative pyrazinoisoquinoline.
This fixed combination, febantel, pyrantel and act against all relevant nematodes (roundworms, hookworms and tricuros) in dogs. In particular, the spectrum of activity covers Toxocara canis, Toxascaris leonina, stenocephala hookworm, Ancylostoma caninum and Trichuris vulpis.
This combination shows synergistic activity in the case of hookworms and febantel is effective against T. vulpis.
The spectrum of activity of praziquantel covers all important species of tapeworm in dogs, particularly Taenia spp., Dipylidium caninum, Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against all forms, whether mature or immature, of these parasites.
Praziquantel is very rapidly absorbed through the surface of the parasite and is distributed throughout the parasite. In vitro and in vivo has been shown to severely damaged tegument praziquantel parasites, leaving them contraction and paralysis. It produces an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolization of the syncytial tegument. This rapid contraction is due to changes in flows of divalent cations, especially calcium.
Pyrantel acts as cholinergic agonist through the stimulation of the nicotinic cholinergic receptors and inducing parasite spastic paralysis in the nematode, allowing remove by peristalsis of the gastrointestinal system.
In mammals, febantel undergoes ring closure and form fenbendazole and oxfendazole. These are chemical entities which exert the anthelmintic effect by inhibiting tubulin polymerization. This prevents the formation of microtubules and the result is a disorder of vital structures for normal operation of the worm. Specifically, the inlet is affected glucose, which causes depletion of ATP in the cells. The parasite dies from the exhaustion of its energy reserves, which happens after 2 or 3 days.
Administered orally, praziquantel is almost completely absorbed in the intestinal tract.
After absorption, the drug is distributed to all organs. Praziquantel is metabolized to inactive forms in the liver and secreted into bile. Is excreted within 24 hours over 95% of the administered dose. Only trace amounts are excreted unmetabolized praziquantel.
In the drug following administration to dogs, reach maximum plasma concentrations of praziquantel at about 2.5 hours.
The pyrantel pamoate salt of low aqueous solubility has a characteristic that reduces its absorption in the gut and allow the active substance to reach and be effective against parasites in the intestine. After absorption, pyrantel pamoate is metabolized so quickly and almost completely inactive metabolites that are rapidly excreted in the urine.
Febantel is relatively quickly absorbed and metabolized in several metabolites including oxfendazole, fenbendazole and which have anthelmintic activity. In the drug following administration to dogs, the maximum concentrations were reached in plasma of fenbendazole and oxfendazole approximately 7-9 hours.
List of excipients
Colloidal anhydrous silica,
Sodium lauryl sulfate.
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Discard unused tablets games.
Special precautions for storage
This medicinal product does not require any special storage conditions
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